Research

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Research

About

The Northwestern Medicine Echocardiography Laboratory supports numerous research initiatives and clinical trials, including investigator-initiated, NIH-funded, and industry-sponsored. Furthermore, we work with multiple companies to support testing and validation of new technologies related to cardiovascular imaging and cardiovascular disease. We have dedicated Core Lab services, statisticians, research sonographers, and administrative support, Additionally, we support clinical and research fellowship in cardiovascular imaging and artificial intelligence.

Below, you will find more information about current areas of research, clinical trials involving echocardiography, recent publications, and echocardiography laboratory faculty areas of research.

Clinical Trials

Information about clinical trials relating to echocardiography are included in the current areas of research described below. Here you can read about all of the clinical trials related to cardiology.

Publications

Recent discoveries within Northwestern Medicine cardiology can be found here.

Current Areas of Research

Tricuspid Valve Therapies

Structural Heart Disease - Echocardiography is frequently used in interventional cardiology procedures. Read about current therapies below that involve echocardiography to improve structural heart diseases.

Tricuspid Valve Therapies

Nothwestern Medicine is currently participating in several trials that involve transcatheter heart valve therapies for the tricuspid valve. Read more on the NM Website. The current trials include:

Clasp II TR Pivotal

The Edwards PASCAL is device is used in patients with tricuspid regurgitation to treat both functional and degenerative tricuspid disease. The PASCAL clip is an edge-to-edge valve repair with a spacer in the center.

Trascend II Pivotal (Animation)

This trial evaluates the safety and effectiveness of the EVOQUE valve replacement with optimal medical therapy (OMT) compared to OMT alone in patients with at least severe tricuspid regurgitation.

Triluminate

The TriClip Tricuspid Valve Repair System is used in patients with severe, symptomatic tricuspid regurgitation and an intermediate or greater risk of mortality for tricuspid valve surgery. Read more about the clinical trial here.

Mitral Valve Therapies

Nothwestern Medicine currently offers several transcatheter heart valve therapies for the mitral valve. Read more on the NM Website. The current commerically available therapies include:

MitraClip (Animation)

The MitraClip is currently the only FDA approved device for transcatheter mitral valve replacement to repair mitral regurgitation.

Transcatheter Mitral Valve in Valve Replacement

This procedure is for patients with a bioprosthetic/tissue valve administered via open heart valve surgery, and the valve is now failing. The TMVR valve is secured inside the failing mitral valve when a balloon on the catheter expands

Current clinical trials include:

REPAIR-MR

This trial is enrolling patients with severe primary MR who are at moderate surgical risk but are suitable candidates for MV surgery. Participants are randomized to receive the MitraClip device or traditional open heart mitral valve repair surgery. Read more about the clinical trial here.

APOLLO

This study is enrolling patients with moderate-to-severe or severe, symptomatic mitral regurgitation who may not respond optimally to transcatheter repair or mitral valve surgery. The study evaluates the effectiveness of the Intrepid Transcatheter Mitral Valve Replacement (TMVR) System.

MISCEND

This study evaluates the Edwards EVOQUE Eos Mitral Valve Replacement System (study device) in patients with moderate to severe mitral regurgitation and high surgical risk.

PASCAL CLASP IIF

This study evaluates the Edwards PASCAL Transcatheter Mitral Valve Repair System (PASCAL System) (study device) in patients with functional mitral regurgitation (FMR) on optimal medical therapy. Participants will be randomized to receive either the PASCAL System or the FDA-approved MitraClip System.

Aortic Valve Therapies

Mitral Valve Therapies

Nothwestern Medicine currently offers several transcatheter heart valve therapies for the mitral valve. Read more on the NM Website. The current commerically available therapies include:

Transcatheter Aortic Valve Replacement (TAVR)

The TAVR is available to patients with aortic stenosis. During the procedure, the TAVR valve is advanced by catheter, then expanded via a balloon on the catheter, pushing the diseased valve out of the way.

Transcatheter Aortic Valve in Valve Replacement

This is a minimally invasive TAVR procedure for patients who have had previous open heart valve surgery to replace the aortic valve with a bioprosthetic/tissue valve that is now failing. The failing aortic valve is replaced by placing and securing a TAVR valve inside the failing aortic valve.

Current clinical trials include:

PARTNER 3 Aortic Valve in Valve

This study is enrolling patients who have an existing bioprosthetic aortic valve that is failing and needs to be replaced. Participants receive the SAPIEN 3 transcatheter aortic heart valve (study device) to replace the failing bioprosthetic aortic valve.

FACULTY AREAS OF RESEARCH AND PUBLICATIONS

Nausheen Akhter, MD

Mohamed M. Al-Kazaz, MD

Research Interests: cardiac-oncology, cardiac imaging, valvular heart disease, and heart disease in women

Publications

Mohamed M. Al-Kazaz, MD

Research Interests:

Publications

Ewa T. Dembowski, MD

Mohamed M. Al-Kazaz, MD

Ewa T. Dembowski, MD

Research Interests:

Publications

Priya M. Freaney

Benjamin H. Freed, MD

Ewa T. Dembowski, MD

Research Interests:

Publications

Benjamin H. Freed, MD

Research Interests:

Publications

Alana A. Lewis, MD

Benjamin H. Freed, MD

Research Interests: cardiology, cardiovascular imaging, valvular heart disease, women in heart disease

Publications

Kameswari Maganti, MD

Research Interests:

Publications

David J. Mehlman, MD

Kameswari Maganti, MD

Research Interests:

Publications

Issam A. Mikati, MD

Kameswari Maganti, MD

Issam A. Mikati, MD

Research Interests:

Publications

Akhil Narang, MD

Jyothy J. Puthumana, MD

Issam A. Mikati, MD

Research Interests:

Publications

Ravi B. Patel, MD

Jyothy J. Puthumana, MD

Research Interests:

Publications

Jyothy J. Puthumana, MD

Research Interests: cardiology, coronary bypass surgery, valvular disease

Publications

Research

About

Clinical Trials

Publications

Current Areas of Research

Tricuspid Valve Therapies

Tricuspid Valve Therapies

Tricuspid Valve Therapies

Tricuspid Valve Therapies

Tricuspid Valve Therapies

Mitral Valve Therapies

Mitral Valve Therapies

Mitral Valve Therapies

Aortic Valve Therapies

Mitral Valve Therapies

Mitral Valve Therapies

FACULTY AREAS OF RESEARCH AND PUBLICATIONS

Nausheen Akhter, MD

Mohamed M. Al-Kazaz, MD

Mohamed M. Al-Kazaz, MD

Mohamed M. Al-Kazaz, MD

Mohamed M. Al-Kazaz, MD

Mohamed M. Al-Kazaz, MD

Ewa T. Dembowski, MD

Mohamed M. Al-Kazaz, MD

Ewa T. Dembowski, MD

Priya M. Freaney

Benjamin H. Freed, MD

Ewa T. Dembowski, MD

Benjamin H. Freed, MD

Benjamin H. Freed, MD

Benjamin H. Freed, MD

Alana A. Lewis, MD

Benjamin H. Freed, MD

Benjamin H. Freed, MD

Kameswari Maganti, MD

Kameswari Maganti, MD

Kameswari Maganti, MD

David J. Mehlman, MD

Kameswari Maganti, MD

Kameswari Maganti, MD

Issam A. Mikati, MD

Kameswari Maganti, MD

Issam A. Mikati, MD

Akhil Narang, MD

Jyothy J. Puthumana, MD

Issam A. Mikati, MD

Ravi B. Patel, MD

Jyothy J. Puthumana, MD

Jyothy J. Puthumana, MD

Jyothy J. Puthumana, MD

Jyothy J. Puthumana, MD

Jyothy J. Puthumana, MD

Vera H. Rigolin, MD

Robert A. Silverberg, MD

Vera H. Rigolin, MD

Sanjiv J. Shah, MD

Robert A. Silverberg, MD

Vera H. Rigolin, MD

Robert A. Silverberg, MD

Robert A. Silverberg, MD

Robert A. Silverberg, MD

James D. Thomas, MD

Allison R. Zielinski, MD

Robert A. Silverberg, MD

Patricia Vassallo, MD

Allison R. Zielinski, MD

Allison R. Zielinski, MD

Allison R. Zielinski, MD

Allison R. Zielinski, MD

Allison R. Zielinski, MD

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